The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.

doi:10.1016/j.pnpbp.2014.01.012

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Article

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Jun 2014

Chen Shiou-Lan, Lee Sheng-Yu, Chang Yun-Hsuan, Chen Shih-Heng, Chu Chun-Hsien, Wang Tzu-Yun, Chen Po-See, Lee I-Hui, Yang Yen-Kuang, Hong Jau-Shyong, Lu Ru-Band

Abstract excerpt

OBJECTIVE: Brain-derived neurotropic factor (BDNF) is widely distributed in the peripheral and central nervous systems. BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. To elucidate the role of BDNF, we compared the plasma BDNF levels and the BDNF Val66Met gene variants effect in several...

Topics

Adult
Analysis of Variance
Asian People
Bipolar Disorder
Brain-Derived Neurotrophic Factor
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Methionine

Middle Aged

Polymorphism, Single Nucleotide

Schizophrenia

Valine

Young Adult

Source

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Identifiers

PMID: 24468644
DOI: 10.1016/j.pnpbp.2014.01.012
PMCID: PMC7137229

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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