ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization.

doi:10.1007/s00406-020-01096-0

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Article

ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization.

European archives of psychiatry and clinical neuroscience - 1 Apr 2021

Scotti-Muzzi Estêvão, Chile Thais, Moreno Ricardo, Pastorello Bruno Fraccini, da Costa Leite Cláudia, Henning Anke, Otaduy Maria Concepcion Garcia, Vallada Homero, Soeiro-de-Souza Márcio Gerhardt

Abstract excerpt

Bipolar disorder (BD) is characterized by unstable mood states ranging from mania to depression. Although there is some evidence that mood instability may result from an imbalance between excitatory glutamatergic and inhibitory GABA-ergic neurotransmission, few proton magnetic resonance spectroscopy (1H-MRS) studies have measured these two neurometabolites simultaneously in BD. The enzyme glutamic acid...

Topics

Adolescent
Adult
Anticonvulsants
Antipsychotic Agents
Bipolar Disorder
Female
Glutamate Decarboxylase
Glutamic Acid
Gyrus Cinguli
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Single Nucleotide

Proton Magnetic Resonance Spectroscopy

Young Adult

gamma-Aminobutyric Acid

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Open in PubMed

Identifiers

PMID: 31993746
DOI: 10.1007/s00406-020-01096-0

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