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Mitochondrial Dysfunction in Alzheimer’s Disease Is Driven By Excess ER-Calcium Release in Patient-Derived Neurons

2024-10-12

Abstract excerpt

Tight regulation of mitochondrial Ca 2+ is essential for neuronal bioenergetics and cellular metabolism. Ca 2+ transfer from ER-localized ryanodine receptors (RyR) and inositol triphosphate receptors (IP 3 R) to the mitochondria maintains a steady Ca 2+ source that fuels oxidative phosphorylation and ATP production. In Alzheimer’s disease (AD), RyR-evoked Ca 2+ release is markedly increased, contributing to s...

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Literature Corpus work
aafedd7d-40e1-5a59-97c3-4c9b209bdc28
DOI
10.1101/2024.10.11.617867
Open publication

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Mitochondrial Dysfunction in Alzheimer’s Disease Is Driven By Excess ER-Calcium Release in Patient-Derived NeuronsDOI 10.1101/2024.10.11.617867
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