Article
Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.
Nature communications - 8 Jan 2018
Wang Changhe, Kang Xinjiang, Zhou Li, Chai Zuying, Wu Qihui, Huang Rong, Xu Huadong, Hu Meiqin, Sun Xiaoxuan, Sun Suhua, Li Jie, Jiao Ruiying, Zuo Panli, Zheng Lianghong, Yue Zhenyu, Zhou Zhuan
Abstract excerpt
Loss-of-function mutations in Parkin are the most common causes of autosomal recessive Parkinson's disease (PD). Many putative substrates of parkin have been reported; their pathogenic roles, however, remain obscure due to poor characterization, particularly in vivo. Here, we show that synaptotagmin-11, encoded by a PD-risk gene SYT11, is a physiological substrate of parkin and plays critical roles in mediating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.