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Article

Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jul 2016

Matikainen-Ankney Bridget A, Kezunovic Nebojsa, Mesias Roxana E, Tian Yuan, Williams Frances M, Huntley George W, Benson Deanna L

Abstract excerpt

UNLABELLED: Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) can cause Parkinson's disease (PD), and the most common disease-associated mutation, G2019S, increases kinase activity. Because LRRK2 expression levels rise during synaptogenesis and are highest in dorsal striatal spiny projection neurons (SPNs), we tested the hypothesis that the LRRK2-G2019S mutation would alter development of...

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Identifiers

PMID: 27383589
DOI: 10.1523/JNEUROSCI.3314-15.2016
PMCID: PMC4938860

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SPN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.PMID 27383589Read ↗

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