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Article

Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.

Human molecular genetics - 15 Feb 2016

Liu Jingnan, Li Tianxia, Thomas Joseph M, Pei Zhong, Jiang Haibing, Engelender Simone, Ross Christopher A, Smith Wanli W

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant Parkinsonism with pleomorphic pathology including deposits of aggregated protein and neuronal degeneration. The pathogenesis of LRRK2-linked Parkinson's disease (PD) is not fully understood. Here, using co-immunoprecipitation, we found that LRRK2 interacted with synphilin-1 (SP1), a cytoplasmic protein that interacts with α-synuclein and...

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Source

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Identifiers

PMID: 26744328
DOI: 10.1093/hmg/ddv504
PMCID: PMC4743687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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