Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Actin-related protein ACTL7B ablation leads to OAT with multiple morphological abnormalities of the flagellum and male infertility in mice

6 Jan 2023

Abstract excerpt

The formation of fertilisation-competent sperm requires spermatid morphogenesis (spermiogenesis), a poorly understood program that involves complex coordinated restructuring and specialised cytoskeletal structures. A major class of cytoskeletal regulators are the actin-related proteins (ARPs), which include conventional actin variants, and related proteins that play essential roles in complexes regulating actin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sperm and Testicular Function

Source

Identifiers

PMID: 36617158
DOI: 10.1093/biolre/ioad001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Actin-related protein ACTL7B ablation leads to OAT with multiple morphological abnormalities of the flagellum and male infertility in micePMID 36617158Read ↗

Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesisSemantic proximity Read ↗

Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertilitySemantic proximity Read ↗

Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by <i>In Vivo</i> Characterizations and AI Facilitated <i>In Silico</i> Mechanistic Modeling with Implications for Epigenetic Regulation in SpermiogenesisSemantic proximity Read ↗

Nucleoporin NUP210L and BAF-paralogue BAF-L together ensure microtubule organization and nuclear integrity in spermatidsSemantic proximity Read ↗

Actin-related ACTL8 localizes to the nucleus and modulates locus-specific transcription through chromatin regulationSemantic proximity Read ↗

Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial OrganizationSemantic proximity Read ↗

Actl7a deficiency in mice leads to male infertility and fertilization failureSemantic proximity Read ↗

Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrestSemantic proximity Read ↗

POU4F2/Brn-3b is Essential for Spermatogenesis and its Disruption is Linked to Male Infertility in Mice and HumansSemantic proximity Read ↗

Leucine-rich Repeat Protein LRRC37A Acts as a Molecular Scaffold Coordinating IAM-PT-NE Complex Assembly and Sperm Head MorphogenesisSemantic proximity Read ↗

ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesisSemantic proximity Read ↗

Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.