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Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertility

3 Feb 2023

Abstract excerpt

Formation of the acrosome during spermiogenesis is an essential process for creating fertilization-competent sperm. Of the numerous aspects required for acrosome biogenesis, adherence of the acrosomal outer membrane to the nuclear surface is mediated by the subacrosomal perinuclear theca. However, the cellular dynamics and congruent functions pertaining to these acrosomal anchoring factors are not well understood...

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Ovarian function and disorders
Reproductive Biology and Fertility
Sperm and Testicular Function

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36734600
DOI: 10.1093/molehr/gaad005

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Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertilityPMID 36734600Read ↗

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Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in miceSemantic proximity Read ↗

Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesisSemantic proximity Read ↗

Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrestSemantic proximity Read ↗

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