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Article

Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis

6 Oct 2023

Abstract excerpt

Actin-related proteins (Arps) are classified according to their similarity to actin and are involved in diverse cellular processes. ACTL7B is a testis-specific Arp, and is highly conserved in rodents and primates. ACTL7B is specifically expressed in round and elongating spermatids during spermiogenesis. Here, we have generated an Actl7b-null allele in mice to unravel the role of ACTL7B in sperm formation. Male...

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PMID: 37800308
DOI: 10.1242/dev.201593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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