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Article

ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis

17 Apr 2023

Abstract excerpt

In sexual reproduction, sperm contribute half the genomic material required for creation of offspring yet core molecular mechanisms essential for their formation are undefined. Here, the α-arrestin molecule arrestin-domain containing 5 (ARRDC5) is identified as an essential regulator of mammalian spermatogenesis. Multispecies testicular tissue transcriptome profiling indicates that expression of Arrdc5 is testis...

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PMID: 37069147
DOI: 10.1038/s41467-023-37735-y

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