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Article

Actin-related ACTL8 localizes to the nucleus and modulates locus-specific transcription through chromatin regulation

2026-08-24

Abstract excerpt

Actin-related proteins (Arps) are evolutionarily ancient and broadly expressed, yet some Arps evolved in mammals and acquired germline-specific expression. Here, we investigate the germline-specific Arp "Actin-like 8" (ACTL8), which is also misexpressed in multiple cancers with unexplored molecular roles. We show that ACTL8 surprisingly localizes to the nucleus of spermatogonia in human testes and breast and lung...

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Literature Corpus work
5d965919-92e7-56e2-872f-74f6236fed43
DOI
10.64898/2026.08.21.746286
Open publication

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