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Article

Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest

28 Aug 2020

Abstract excerpt

ACTL7A deficiency is a novel male factor inducing early embryonic arrest that can be overcome by artificial oocyte activation.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32923619
DOI: 10.1126/sciadv.aaz4796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrestPMID 32923619Read ↗

Actl7a deficiency in mice leads to male infertility and fertilization failureSemantic proximity Read ↗

Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertilitySemantic proximity Read ↗

Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesisSemantic proximity Read ↗

Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failureSemantic proximity Read ↗

A novel homozygous mutation in ACTL7A leads to male infertility.Semantic proximity Read ↗

Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failureSemantic proximity Read ↗

Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and miceSemantic proximity Read ↗

A novel gene ACTRT3 mutations induce sperm malformations and fertilization failure via Acrosomal ultrastructural defects.Semantic proximity Read ↗

Novel ACTL7A variants in males lead to fertilization failure and male infertility.Semantic proximity Read ↗

Unraveling the mysteries of early embryonic arrest: genetic factors and molecular mechanisms.Semantic proximity Read ↗

Actin-related protein ACTL7B ablation leads to OAT with multiple morphological abnormalities of the flagellum and male infertility in miceSemantic proximity Read ↗

Pathogenic variant in ACTL7A causes severe teratozoospermia characterized by bubble-shaped acrosomes and male infertilitySemantic proximity Read ↗

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