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Article

Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice

26 May 2022

Abstract excerpt

The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus; however, the physiological roles of the PT in sperm are largely uncertain. Here, we reveal that ACTRT1, ACTRT2, ACTL7A and ACTL9 proteins interact to form a multimeric complex and localize to the subacrosomal region of spermatids. Furthermore, we engineered Actrt1-knockout (KO) mice to define the functions of ACTRT1. Despite...

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PMID: 35616329
DOI: 10.1242/dev.200489

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