Article
Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2024
Laskar R S, Qu C, Huyghe J R, Harrison T, Hayes R B, Cao Y, Campbell P T, Steinfelder R, Talukdar F R, Brenner H, Ogino S, Brendt S, Bishop D T, Buchanan D D, Chan A T, Cotterchio M, Gruber S B, Gsur A, van Guelpen B, Jenkins M A, Keku T O, Lynch B M, Le Marchand L, Martin R M, McCarthy K, Moreno V, Pearlman R, Song M, Tsilidis K K, Vodička P, Woods M O, Wu K, Hsu L, Gunter M J, Peters U, Murphy N
Abstract excerpt
BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. CRC has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian...
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