Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer.

doi:10.1093/ije/dyw129

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Article

Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer.

International journal of epidemiology - 1 Jun 2016

Gao Chi, Patel Chirag J, Michailidou Kyriaki, Peters Ulrike, Gong Jian, Schildkraut Joellen, Schumacher Fredrick R, Zheng Wei, Boffetta Paolo, Stucker Isabelle, Willett Walter, Gruber Stephen, Easton Douglas F, Hunter David J, Sellers Thomas A, Haiman Christopher, Henderson Brian E, Hung Rayjean J, Amos Christopher, Pierce Brandon L, Lindström Sara, Kraft Peter

Abstract excerpt

BACKGROUND: Adiposity traits have been associated with risk of many cancers in observational studies, but whether these associations are causal is unclear. Mendelian randomization (MR) uses genetic predictors of risk factors as instrumental variables to eliminate reverse causation and reduce confounding bias. We performed MR analyses to assess the possible causal relationship of birthweight, childhood and adult...

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Identifiers

PMID: 27427428
DOI: 10.1093/ije/dyw129
PMCID: PMC6372135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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