Back to search

Article

Associations between vitamin D and disease risk may be attributed to the confounding influence of adiposity during childhood and adulthood: a lifecourse Mendelian randomization study

2022-05-16

Abstract excerpt

<h4>Background</h4> Vitamin D supplements are widely prescribed to help reduce disease risk. However, this strategy is based on findings using conventional epidemiological methods which are prone to confounding and reverse causation. <h4>Methods</h4> In this short report, we leveraged genetic variants which differentially influence body size during childhood and adulthood within a multivariable Mendelian randomi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d34a7d11-c2a8-59e3-b80c-4aa33195e963
DOI
10.1101/2022.05.11.22274956
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Associations between vitamin D and disease risk may be attributed to the confounding influence of adiposity during childhood and adulthood: a lifecourse Mendelian randomization studyDOI 10.1101/2022.05.11.22274956
Adiposity may confound the association between vitamin D and disease risk - a lifecourse Mendelian randomization study.Semantic proximity
Age-specific effects of body size on fracture risk in later life: A lifecourse Mendelian randomization studySemantic proximity
Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approachSemantic proximity
Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysisSemantic proximity
Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.Semantic proximity
Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization.Semantic proximity
Phenome-wide investigation of the causal associations between childhood BMI and adult outcomes: A two-sample Mendelian randomization studySemantic proximity
Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization studySemantic proximity
Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization.Semantic proximity
Evaluating the direct effects of childhood adiposity on adult systemic-metabolism: A multivariable Mendelian randomization analysisSemantic proximity
Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body SizeSemantic proximity
A systematic literature review of methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiologySemantic proximity
Select a neighboring publication to make it the new centre.