Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.

BMJ (Clinical research ed.) - 6 May 2020

Richardson Tom G, Sanderson Eleanor, Elsworth Benjamin, Tilling Kate, Davey Smith George

Abstract excerpt

OBJECTIVE: To evaluate whether body size in early life has an independent effect on risk of disease in later life or whether its influence is mediated by body size in adulthood. DESIGN: Two sample univariable and multivariable mendelian randomisation. SETTING: The UK Biobank prospective cohort study and four large scale genome-wide association studies (GWAS) consortiums. PARTICIPANTS: 453 169 participants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Artery Disease

Share to Diabetes Mellitus, Type 2

Share to Mendelian Randomization Analysis

Share to Obesity

Share to Prostatic Neoplasms

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 32376654
DOI: 10.1136/bmj.m1203
PMCID: PMC7201936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.PMID 32376654Read ↗

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization studySemantic proximity Read ↗

Adiposity may confound the association between vitamin D and disease risk - a lifecourse Mendelian randomization study.Semantic proximity Read ↗

Evaluating the direct effects of childhood adiposity on adult systemic-metabolism: A multivariable Mendelian randomization analysisSemantic proximity Read ↗

Associations between vitamin D and disease risk may be attributed to the confounding influence of adiposity during childhood and adulthood: a lifecourse Mendelian randomization studySemantic proximity Read ↗

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.Semantic proximity Read ↗

Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body SizeSemantic proximity Read ↗

A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structureSemantic proximity Read ↗

Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysisSemantic proximity Read ↗

Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization.Semantic proximity Read ↗

Disentangling the direct and indirect effects of childhood adiposity on type 1 diabetes and immune-associated diseases: a multivariable Mendelian randomization studySemantic proximity Read ↗

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis.Semantic proximity Read ↗

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.