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Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

13 Dec 2022

Abstract excerpt

Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied for their potential use in turning transgene expression on or off by ligand binding. We compared several tetracycline and toyocamycin-inducible ON-riboswitches for a drug responsive transgene expression. The tetracycline-dependent K19 riboswitch showed the...

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PMID: 36582287
DOI: 10.3389/fmed.2022.1052318

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