Article

Small molecule-controlled gene expression: Design of drug-like high affinity small molecule modulators of a custom-made riboswitch

2025-01-21

Abstract excerpt

Riboswitches are regulatory RNA structures that modulate gene expression in response to a small molecule. Until now, efforts to design ligand analogs were motivated by their potential antibiotic activity. However, riboswitches are ideally suited as tools for gene therapy, enabling precise control of gene ex-pression without the need of potentially immunogenic regulatory proteins. Developing synthetic RNA switches...

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Literature Corpus work: 2699d379-aef7-5234-a01e-9a19940b3cca
DOI: 10.1101/2025.01.21.634073

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