Article

pA regulator: a system for controlling mammalian gene expression via the modulation of polyA signal cleavage

2023-01-28

Abstract excerpt

The ability to control the expression of a therapeutic gene or a transgene in mammalian cells is crucial for safe and efficacious gene and cell therapy, as well as for elucidating the function of a specific gene product. Yet current mammalian gene regulation systems either evoke harmful immune responses in hosts or lack the required regulatory efficiency. Here we describe a highly responsive RNA-based molecular sw...

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Literature Corpus work: 02177360-55e6-51c4-90b4-dec2f794f232
DOI: 10.1101/2023.01.27.525935

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