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Parkin Knockdown Modulates Dopamine Release in the Central Complex, but Not the Mushroom Body Heel, of Aging Drosophila

28 Dec 2022

Abstract excerpt

Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons leading to reduced locomotion. Mutations of parkin gene in Drosophila produce the same phenotypes as vertebrate models, but the effect of parkin knockdown on dopamine release is not known. Here, we report age-dependent, spatial variation of dopamine release in the brain of parkin -RNAi adult Drosophila . Dopamine was...

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PMID: 36576890
DOI: 10.1021/acschemneuro.2c00277

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