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Article

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.

The Journal of biological chemistry - 31 Oct 2003

Goldberg Matthew S, Fleming Sheila M, Palacino James J, Cepeda Carlos, Lam Hoa A, Bhatnagar Anushree, Meloni Edward G, Wu Nanping, Ackerson Larry C, Klapstein Gloria J, Gajendiran Mahadevan, Roth Bryan L, Chesselet Marie-Francoise, Maidment Nigel T, Levine Michael S, Shen Jie

Abstract excerpt

Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease. To investigate the pathogenic mechanism by which loss of parkin function causes Parkinson's disease, we generated a mouse model bearing a germline disruption in parkin. Parkin-/- mice are viable...

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Identifiers

PMID: 12930822
DOI: 10.1074/jbc.M308947200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12930822-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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