Article

Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

2025-08-21

Abstract excerpt

<title>Abstract</title> <p>Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, we uncovered a neural mechanism underlying this p...

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Literature Corpus work: 6e65ffd2-3098-52fa-8ceb-d45d95834e3d
DOI: 10.21203/rs.3.rs-6957787/v1

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