Article

Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

2025-07-04

Abstract excerpt

Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, we uncovered a neural mechanism underlying this phenomenon. While catecholami...

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Literature Corpus work: d3bf91b1-962c-5e18-9c69-2231b4b30319
DOI: 10.1101/2025.06.30.662454

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