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Article

Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages.

Redox biology - 1 Feb 2023

Maassen Sjors, Coenen Britt, Ioannidis Melina, Harber Karl, Grijpstra Pieter, Van den Bossche Jan, van den Bogaart Geert

Abstract excerpt

Pathological conditions associated with dysfunctional wound healing are characterized by impaired remodelling of extracellular matrix (ECM), increased macrophage infiltration, and chronic inflammation. Macrophages also play an important role in wound healing as they drive wound closure by secretion of molecules like transforming growth factor beta-1 (TGF-β). As the functions of macrophages are regulated by their...

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Identifiers

PMID: 36574745
DOI: 10.1016/j.redox.2022.102591
PMCID: PMC9800195

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