Article

4-Octyl Itaconate attenuates ARDS by regulating M1/M2 polarization via inhibiting Drp1 mediated mtDNA and mito-ROS leakage

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>Background Acute respiratory distress syndrome (ARDS) is a serious inflammatory disorder associated with substantial morbidity and mortality. 4-Octyl Itaconate (4-OI) could ameliorate ARDS by regulating the macrophage polarization However, the role and mechanisms of 4-OI in ARDS are still poorly understood. Methods Our research investigated the role of 4-OI in attenuating ARDS by modu...

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Literature Corpus work: af04b3ec-b9b4-50b1-b0f7-50cd7d088060
DOI: 10.21203/rs.3.rs-9462984/v1

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