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Article

Collagenase-based wound debridement agent induces extracellular matrix supporting phenotype in macrophages.

Scientific reports - 8 Feb 2024

Banerjee Pradipta, Das Amitava, Singh Kanhaiya, Khanna Savita, Sen Chandan K, Roy Sashwati

Abstract excerpt

Macrophages assume diverse phenotypes and functions in response to cues from the microenvironment. Earlier we reported an anti-inflammatory effect of Collagenase Santyl® Ointment (CSO) and the active constituent of CSO (CS-API) on wound macrophages in resolving wound inflammation indicating roles beyond debridement in wound healing. Building upon our prior finding, this study aimed to understand the phenotypes...

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Identifiers

PMID: 38331988
DOI: 10.1038/s41598-024-53424-2
PMCID: PMC10853180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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