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PolyQ-Expanded Mutant Huntingtin Forms Inclusion Body Following Transient Cold Shock in a Two-Step Aggregation Mechanism.

ACS chemical neuroscience - 18 Jan 2023

Castro E Costa Ana Raquel, Mysore Sachin, Paruchuri Praneet, Chen Kuang Yu, Liu Alice Y

Abstract excerpt

Age-dependent formation of insoluble protein aggregates is a hallmark of many neurodegenerative diseases. We are interested in the cell chemistry that drives the aggregation of polyQ-expanded mutant Huntingtin (mHtt) protein into insoluble inclusion bodies (IBs). Using an inducible cell model of Huntington's disease, we show that a transient cold shock (CS) at 4 °C followed by recovery incubation at temperatures...

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PMID: 36574489
DOI: 10.1021/acschemneuro.2c00585

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