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Article

Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models.

Scientific reports - 23 Sept 2020

Aravindan Shreyaas, Chen Samantha, Choudhry Hannaan, Molfetta Celine, Chen Kuang Yu, Liu Alice Y C

Abstract excerpt

Osmolytes are organic solutes that change the protein folding landscape shifting the equilibrium towards the folded state. Herein, we use osmolytes to probe the structuring and aggregation of the intrinsically disordered mutant Huntingtin (mHtt) vis-a-vis the pathogenicity of mHtt on transcription factor function and cell survival. Using an inducible PC12 cell model of Huntington's disease (HD), we show that...

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Identifiers

PMID: 32968182
DOI: 10.1038/s41598-020-72613-3
PMCID: PMC7511939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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