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Article

Hsp70 dynamics in vivo: effect of heat shock and protein aggregation.

Journal of cell science - 1 Oct 2004

Zeng Xian-Chun, Bhasin Samir, Wu Xufeng, Lee Joeng-Goo, Maffi Shivani, Nichols Christopher J, Lee Kyung Jin, Taylor J Paul, Greene Lois E, Eisenberg Evan

Abstract excerpt

The molecular chaperone Hsp70 interacts with misfolded proteins and also accumulates in the nucleus during heat shock. Using GFP-Hsp70 and fluorescence recovery after photobleaching, we show that Hsp70 accumulates in the nucleus during heat shock not only because its inflow rate increases but also because of a marked decrease in its outflow rate. Dynamic imaging also shows that GFP-Hsp70 has greatly reduced...

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Identifiers

PMID: 15367583
DOI: 10.1242/jcs.01373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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