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Article

Anisosmotic Modulation of Mutant Huntingtin Aggregation vis-a-vis HSP70 Induction─Implications for Aging, Hypo-Hydration, and Neurodegeneration.

ACS chemical neuroscience - 4 Mar 2026

Liu Alice Y C, Kwan Kelvin Y, Kwan Clarissa, Chen Kuang Yu

Abstract excerpt

Suboptimal cell hydration is a significant risk factor for age-related deterioration and disease vulnerability. Herein, we use a Huntington disease cell model to evaluate osmolarity-dependent modulation of (1) aggregation of polyQ-expanded mutant Huntingtin-EGFP reporter protein as a readout for structurally dynamic disease proteins versus (2) induction of HSP70 chaperone to report on stress-induced lability of...

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Identifiers

PMID: 41702590
DOI: 10.1021/acschemneuro.5c00966
PMCID: PMC12964416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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