Article

Nuclear bodies protect phase separated proteins from degradation in stressed proteome

2023-04-21

Abstract excerpt

RNA-binding proteins (RBPs) containing intrinsically disordered domains undergo liquid-liquid phase separation to form nuclear bodies under stress conditions. This process is also connected to the misfolding and aggregation of RBPs, which are associated with a series of neurodegenerative diseases. However, it remains elusive how folding states of RBPs changes upon the formation and maturation of nuclear bodies. He...

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Literature Corpus work: dac1b07d-fad3-5119-850f-32ab950623d7
DOI: 10.1101/2023.04.19.537522

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