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Article

Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process.

Journal of the American Chemical Society - 19 Jul 2023

Choudhary Dhawal, Mediani Laura, Avellaneda Mario J, Bjarnason Sveinn, Alberti Simon, Boczek Edgar E, Heidarsson Pétur O, Mossa Alessandro, Carra Serena, Tans Sander J, Cecconi Ciro

Abstract excerpt

Small Heat Shock Proteins (sHSPs) are key components of our Protein Quality Control system and are thought to act as reservoirs that neutralize irreversible protein aggregation. Yet, sHSPs can also act as sequestrases, promoting protein sequestration into aggregates, thus challenging our understanding of their exact mechanisms of action. Here, we employ optical tweezers to explore the mechanisms of action of the...

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PMID: 37411010
DOI: 10.1021/jacs.3c02022
PMCID: PMC10360156

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