MDM4 rs4245739 A > C polymorphism correlates with reduced overall cancer risk in a meta-analysis of 69477 subjects.

doi:10.18632/oncotarget.12326

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Article

MDM4 rs4245739 A > C polymorphism correlates with reduced overall cancer risk in a meta-analysis of 69477 subjects.

Oncotarget - 1 Nov 2016

Xu Chaoyi, Zhu Jinhong, Fu Wen, Liang Zongwen, Song Shujie, Zhao Yuan, Lyu Lihua, Zhang Anqi, He Jing, Duan Ping

Abstract excerpt

Mouse double minute 4 (MDM4) is a p53-interacting oncoprotein that plays an important role in the p53 tumor suppressor pathway. The common rs4245739 A > C polymorphism creates a miR-191 binding site in the MDM4 gene transcript. Numerous studies have investigated the association between this MDM4 polymorphism and cancer risk, but have failed to reach a definitive conclusion. To address this issue, we conducted a...

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PMID: 27687591
DOI: 10.18632/oncotarget.12326
PMCID: PMC5342115

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MDM4

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