MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.

doi:10.1002/cam4.555

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Article

MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.

Cancer medicine - 1 Dec 2015

Gansmo Liv B, Romundstad Pål, Birkeland Einar, Hveem Kristian, Vatten Lars, Knappskog Stian, Lønning Per Eystein

Abstract excerpt

The MDM4 protein plays an important part in the negative regulation of the tumor suppressor p53 through its interaction with MDM2. In line with this, MDM4 amplification has been observed in several tumor forms. A polymorphism (rs4245739 A>C; SNP34091) in the MDM4 3' untranslated region has been reported to create a target site for hsa-miR-191, resulting in decreased MDM4 mRNA levels. In this population-based...

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PMID: 26471763
DOI: 10.1002/cam4.555
PMCID: PMC5123711

Genes

MDM4
MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.PMID 26471763Read ↗

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Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility.Semantic proximity Read ↗

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