Article
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility.
Breast cancer research and treatment - 1 Jul 2013
Liu Jibing, Tang Xiaohu, Li Meng, Lu Chao, Shi Juan, Zhou Liqing, Yuan Qipeng, Yang Ming
Abstract excerpt
The oncoprotein MDM4 plays an essential role in P53 tumor suppressor pathway through negative regulation of P53 function. It has been reported that the rs4245739 A > C polymorphism located in the MDM4 3'-untranslated region creates a miR-191 target site and results in decreased MDM4 expression. Therefore, we investigated the association of the MDM4 rs4245739 polymorphism as well as the P53 Arg72Pro genetic...
Topics
- Asian People
- Breast Neoplasms
- Case-Control Studies
- Cell Cycle Proteins
- China