Article
Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma.
PloS one - 1 Jan 2013
Zhou Liqing, Zhang Xiaojiao, Li Ziqiang, Zhou Changchun, Li Meng, Tang Xiaohu, Lu Chao, Li Helou, Yuan Qipeng, Yang Ming
Abstract excerpt
As an oncoprotein, MDM4 plays a key part in P53 tumor suppressor pathway through negatively regulating P53 function. It has been reported that an rs4245739 A>C polymorphism locating in the MDM4 3'-untranslated region creates a miR-191 target site and results in decreased MDM4 expression. Therefore, we investigated the association between this polymorphism and esophageal squamous cell carcinoma (ESCC) risk as well...
Topics
- Binding Sites
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cell Cycle Proteins
- Esophageal Neoplasms
- Esophageal Squamous Cell Carcinoma
- Female
- Gene Expression Regulation, Neoplastic