Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma.

doi:10.1371/journal.pone.0064331

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Article

Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma.

PloS one - 1 Jan 2013

Zhou Liqing, Zhang Xiaojiao, Li Ziqiang, Zhou Changchun, Li Meng, Tang Xiaohu, Lu Chao, Li Helou, Yuan Qipeng, Yang Ming

Abstract excerpt

As an oncoprotein, MDM4 plays a key part in P53 tumor suppressor pathway through negatively regulating P53 function. It has been reported that an rs4245739 A>C polymorphism locating in the MDM4 3'-untranslated region creates a miR-191 target site and results in decreased MDM4 expression. Therefore, we investigated the association between this polymorphism and esophageal squamous cell carcinoma (ESCC) risk as well...

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PMID: 23724042
DOI: 10.1371/journal.pone.0064331
PMCID: PMC3665831

Genes

MDM4

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Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma.PMID 23724042Read ↗

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