Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia

21 Dec 2022

Abstract excerpt

Importance: Predictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are lacking. Longitudinally ascertained medication use may empower studies examining associations between polygenic risk scores (PRSs) and pharmacotherapy choices. Objective: To examine associations between PRS-SCZ loading and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Schizophrenia research and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36542388
DOI: 10.1001/jamapsychiatry.2022.4234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With SchizophreniaPMID 36542388Read ↗

Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systemsSemantic proximity Read ↗

Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scoresSemantic proximity Read ↗

Pharmacogenomic scores in psychiatry: Systematic review of existing evidenceSemantic proximity Read ↗

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorderSemantic proximity Read ↗

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disordersSemantic proximity Read ↗

Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric DisordersSemantic proximity Read ↗

Subtyping Schizophrenia Using Psychiatric Polygenic ScoresSemantic proximity Read ↗

Polygenetic risk scores and phenotypic constellations of obsessive-compulsive disorder in clozapine-treated schizophrenia.Semantic proximity Read ↗

A Systematic Review and Analysis of the Use of Polygenic Scores in Pharmacogenomics.Semantic proximity Read ↗

Polygenic risk score and the psychosis continuum model.Semantic proximity Read ↗

Polygenic Liability for Antipsychotic Dosage and Polypharmacy - A Real-World Registry and Biobank StudySemantic proximity Read ↗

Polygenic risk scores lack prognostic value for adults with severe mental illnessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.