Article

Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores

2022-02-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Treatment-resistant schizophrenia (TRS) affects ∼30% of individuals with the disorder. Clozapine is the medication of choice in TRS but optimizing administration and dose titration are complex. The identification of predictive factors that influence clozapine prescription and response, including genetics, is of clinical interest in a precision psychiatry framework. We aimed to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4fc1a442-5e99-5d2f-bbb1-2941406e79b3
DOI: 10.1101/2022.02.18.22271204

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scoresDOI 10.1101/2022.02.18.22271204Read

Polygenic Liability for Antipsychotic Dosage and Polypharmacy - A Real-World Registry and Biobank StudySemantic proximity Read

Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring dataSemantic proximity Read

Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UKSemantic proximity Read

Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With SchizophreniaSemantic proximity Read

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessmentSemantic proximity Read

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia.Semantic proximity Read

Subtyping Schizophrenia Using Psychiatric Polygenic ScoresSemantic proximity Read

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disordersSemantic proximity Read

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorderSemantic proximity Read

Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia.Semantic proximity Read

Prediction of antipsychotics efficacy based on a polygenic risk score: a real-world cohort studySemantic proximity Read

Treatment-Resistant Schizophrenia, Clozapine Resistance, Genetic Associations, and Implications for Precision Psychiatry: A Scoping ReviewSemantic proximity Read