Article

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorder

2021-06-07

Abstract excerpt

Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PRS) analyses to estimate the amount of variance in symptom severity among clozapine-treated patients explained by PRSs (R2) and examined the association between symptom...

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Literature Corpus work: 5a5a260d-529c-5e89-8ba5-666f910d7a91
DOI: 10.1101/2021.06.06.21258200

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