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Article

Polygenetic risk scores and phenotypic constellations of obsessive-compulsive disorder in clozapine-treated schizophrenia.

European archives of psychiatry and clinical neuroscience - 1 Feb 2024

Morgenroth Carla Lou, Kleymann Philipp, Ripke Stephan, Awasthi Swapnil, Wagner Elias, Oviedo-Salcedo Tatiana, Okhuijsen-Pfeifer Cynthia, Luykx Jurjen J, van der Horst Marte Z, Hasan Alkomiet, Bermpohl Felix, Gutwinski Stefan, Schreiter Stefanie

Abstract excerpt

Obsessive-compulsive symptoms (OCS) are frequently observed in individuals with schizophrenia (SCZ) treated with clozapine (CLZ). This study aimed to analyze prevalence of OCS and obsessive-compulsive disorder (OCD) in this subgroup and find possible correlations with different phenotypes. Additionally, this is the first study to examine polygenetic risk scores (PRS) in individuals with SCZ and OCS. A multicenter...

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Identifiers

PMID: 37020043
DOI: 10.1007/s00406-023-01593-y
PMCID: PMC10786740

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