Article
Diversity is key for cross-ancestry transferability of glaucoma genetic risk scores in Hispanic Veterans in the Million Veteran Program.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2023
Waksmunski Andrea R, Kinzy Tyler G, Cruz Lauren A, Nealon Cari L, Halladay Christopher W, Anthony Scott A, Greenberg Paul B, Sullivan Jack M, Wu Wen-Chih, Iyengar Sudha K, Crawford Dana C, Peachey Neal S, Cooke Bailey Jessica N
Abstract excerpt
A major goal of precision medicine is to stratify patients based on their genetic risk for a disease to inform future screening and intervention strategies. For conditions like primary open-angle glaucoma (POAG), the genetic risk architecture is complicated with multiple variants contributing small effects on risk. Following the tepid success of genome-wide association studies for high-effect disease risk variant...
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