Article

Whole-genome sequence genome-wide association study in <i>All of Us</i> identifies a novel glaucoma risk locus in African ancestry individuals

2026-03-22

Abstract excerpt

<h4>Objective</h4> To assess how whole genome sequencing and varying phenotype definitions influence genetic discovery for primary open-angle glaucoma (POAG) in a diverse population. <h4>Design</h4> Ancestry-stratified genome-wide association studies (GWASs) and cross-ancestry meta-analyses of POAG cases and controls using two phenotype definitions. <h4>Participants</h4> Cases (age > 40) and controls (age > 6...

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Literature Corpus work: 68214149-8018-5bee-b409-738b38c1f89c
DOI: 10.64898/2026.03.19.26348739

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