Article
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.
Nature genetics - 1 Dec 2024
Gorman Bryan R, Voloudakis Georgios, Igo Robert P, Kinzy Tyler, Halladay Christopher W, Bigdeli Tim B, Zeng Biao, Venkatesh Sanan, Cooke Bailey Jessica N, Crawford Dana C, Markianos Kyriacos, Dong Frederick, Schreiner Patrick A, Zhang Wen, Hadi Tamer, Anger Matthew D, Stockwell Amy, Melles Ronald B, Yin Jie, Choquet Hélène, Kaye Rebecca, Patasova Karina, Patel Praveen J, Yaspan Brian L, Jorgenson Eric, Hysi Pirro G, Lotery Andrew J, Gaziano J Michael, Tsao Philip S, Fliesler Steven J, Sullivan Jack M, Greenberg Paul B, Wu Wen-Chih, Assimes Themistocles L, Pyarajan Saiju, Roussos Panos, Peachey Neal S, Iyengar Sudha K
Abstract excerpt
To effectively reduce vision loss due to age-related macular generation (AMD) on a global scale, knowledge of its genetic architecture in diverse populations is necessary. A critical element, AMD risk profiles in African and Hispanic/Latino ancestries, remains largely unknown. We combined data in the Million Veteran Program with five other cohorts to conduct the first multi-ancestry genome-wide association study...
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