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Article

Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations.

Nature communications - 22 Jul 2022

Gao Linfeng, Guo Yiran, Biswal Mahamaya, Lu Jiuwei, Yin Jiekai, Fang Jian, Chen Xinyi, Shao Zengyu, Huang Mengjiang, Wang Yinsheng, Wang Gang Greg, Song Jikui

Abstract excerpt

DNA methyltransferase DNMT3B plays an essential role in establishment of DNA methylation during embryogenesis. Mutations of DNMT3B are associated with human diseases, notably the immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome. How ICF mutations affect DNMT3B activity is not fully understood. Here we report the homo-oligomeric structure of DNMT3B methyltransferase domain, providing...

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Identifiers

PMID: 35869095
DOI: 10.1038/s41467-022-31933-w
PMCID: PMC9307851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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