Article
Structural basis for DNMT3A-mediated de novo DNA methylation.
Nature - 15 Feb 2018
Zhang Zhi-Min, Lu Rui, Wang Pengcheng, Yu Yang, Chen Dongliang, Gao Linfeng, Liu Shuo, Ji Debin, Rothbart Scott B, Wang Yinsheng, Wang Gang Greg, Song Jikui
Abstract excerpt
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at cytosines is essential for genome regulation and development. Dysregulation of this process is implicated in various diseases, notably cancer. However, the mechanisms underlying DNMT3 substrate recognition and enzymatic specificity remain elusive. Here we report a 2.65-ångström crystal structure of the DNMT3A-DNMT3L-DNA complex in...
Topics
- Binding Sites
- Cell Proliferation
- CpG Islands
- Crystallography, X-Ray
- DNA
- DNA (Cytosine-5-)-Methyltransferases
- DNA Methylation
- DNA Methyltransferase 3A
- DNA-Binding Proteins
- Hematologic Neoplasms
- Humans
- Models, Molecular
- Mutation