Article
Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9.
Scientific reports - 4 May 2020
Pinzon-Arteaga Carlos, Snyder Matthew D, Lazzarotto Cicera R, Moreno Nicolas F, Juras Rytis, Raudsepp Terje, Golding Michael C, Varner Dickson D, Long Charles R
Abstract excerpt
Phenotypic selection during animal domestication has resulted in unwanted incorporation of deleterious mutations. In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBED) is the result of one of these deleterious mutations (102C > A), in the first exon of the GBE1 gene (GBE1102C>A). With recent advances in genome editing, this type of genetic mutation can be precisely...
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