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An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration

14 Dec 2022

Abstract excerpt

Intronic polymorphic TOMM40 variants increasing TOMM40 mRNA expression are strongly correlated to late onset Alzheimer's Disease. The gene product, hTomm40, encoded in the APOE gene cluster, is a core component of TOM, the translocase that imports nascent proteins across the mitochondrial outer membrane. We used Drosophila melanogaster eyes as an in vivo model to investigate the relationship between elevated...

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PMID: 36517509
DOI: 10.1038/s41598-022-23280-z

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