Article
Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2.
Neurobiology of disease - 1 May 2021
Ngolab Jennifer, Canchi Saranya, Rasool Suhail, Elmaarouf Abderrahman, Thomas Kimberly, Sarsoza Floyd, Grundman Jennifer, Mante Michael, Florio Jazmin, Nandankar Nimisha, Korouri Shaina, Zago Wagner, Masliah Eliezer, Rissman Robert A
Abstract excerpt
The microtubule-associated protein tau is implicated in multiple degenerative diseases including retinal diseases such as glaucoma; however, the way tau initiates retinopathy is unclear. Previous retinal assessments in mouse models of tauopathy suggest that mutations in four-repeat (4R) tau are associated with disease-induced retinal dysfunction, while shifting tau isoform ratio to favor three-repeat (3R) tau...
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