Article

ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration

2020-01-09

Abstract excerpt

Animals have evolved multiple mechanisms to protect themselves from the cumulative effects of age-related cellular damage. Here we reveal an unexpected link between the TNF (tumour necrosis factor) inflammatory pathway, triggered by the metalloprotease ADAM17/TACE, and a lipid droplet (LD)-mediated mechanism of protecting retinal cells from age related degeneration. Loss of ADAM17, TNF and the TNF receptor Grindel...

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Literature Corpus work: 044f817c-9649-50bf-83f7-4dfe9f595a39
DOI: 10.1101/2020.01.09.900209

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